|Name||Mr. Chao Cui|
|Organization or Institution||University of Florida|
|Topic||Biochemistry / Chem Bio.|
Nano-formulation of anticancer drugs improves deep tissue penetration
Xiaowei Ma, Ping Zhang, Chao Cui, Ying Wang, Ramprasad Ghosh, Qifang Wang, Nathaniel L. Matteson, Valerie Perea, Kate Sheehan, David T. Cramb, Chang-Chun Ling, and Lina Cui
Departments of Medicinal Chemistry, College of Pharmacy, UF Health Science Center, UF Health Cancer Center, University of Florida.
Systemic treatment of cancer using long-circulating nanomedicines is promising due to their passive tumor targeting ability to achieve higher and more selective accumulation in tumors with irregular vascularization, a phenomenon known as extended permeation and retention (EPR) effect. Clinical use of nanometer-sized carriers, such as Doxil and Abraxane, to deliver chemotherapeutics to solid tumors is proven effective in highly vascularized tumors such as breast cancer, ovarian cancer, multiple myeloma, and Kaposi’s sarcoma. Most nanomedicines that are being developed or approved so far have a diameter of around 100-200 nm for prolonged retention in highly angiogenic and densely vascularized tumors, however, they suffer from limited accumulation and poor penetration to the inner core of avascular or hypovascular tumors (such as prostate and pancreatic cancer), therefore nanomedicines small than 100 nm are more preferred for improved tumor penetration. Here we present our strategy to form cyclodextrin-based sub-30-nm nanocarriers, which allows easy drug encapsulation, and successful delivery of therapeutics to human tumor xenografts with significantly reduced tumor growth rates and improved survival rates.